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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f455d269a9e0389bcd4ff3f16ef416b45eb2b08d52cf829ee890b06c48f43944' 
  AND token = 'uRJEwD7YnRXi6RBIqK/zcYQC70PqCe9EmzPi4sEgoMc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}