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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb54def914ba32913ce904798a6a108d7a4140eaced7e9d7212d15b1689bcb3c' 
  AND token = 'wd2XlR49PqdNb51c+1mZIT/s59SBvF9d3DTUIbua92U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}