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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e441d619d271ae94bcc5340da02d4926ff42f5e47aa211c1595e255afcd51420' 
  AND token = '5U+ZxQrzpeBsIP2k7uQk/H1eUsvZhJCNSQSmx376oHs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}