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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '537bcf8bcabf46ed9c1489c344f8e085f748856c18675ede5dad5b8ea2e625af' 
  AND token = 'aSLekYwm3s1laxPjnIDx6TvRiq6q4wk+HQ0nTXvDTl0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}