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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5291e7c9c1ce91c31cfbdf56f386465f2dca2aed185b10a50fa55d1fe610b346' 
  AND token = 'Jk1N+1PHVswSZAtSktHKlSyc2P65pcb++uBdRKfaZmA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}