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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3853fef966f2aeff5d09edbc05cc7167de419a86b3ddbde0622ced6d08acdbeb' 
  AND token = 'cqlwj0d5gRJrfCFm7V6cbSzN1rLVclOL7SLA2MAtgSU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}