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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cedeeb071eb8f27ce9cc26496bb0590a735bbfddaa9646a768807db1b4ef6599' 
  AND token = 'UV8feUWkL6ybO7EDrmI1FxTB8HCSrW7I46RcaNTme7E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}