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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3f7ebdbe7c9cdfb3aefd4909a602851b0cd9b760e983c253a8c01a73b74b4523' 
  AND token = '+XPowuLp6hqycEKyTFcnCOp1UnnkT7xUzorTTazg2+w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}